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Cells were seeded onto sterile poly-D-lysinecoated coverslips (A3890401, Thermo Fisher Scientific) and allowed to adhere for 4 h

Hydroxyl radicals OV-6: Anti-oval cell marker antibody PA: Palmitoyl ascorbate PAMAM: Polyamidoamine PBAE ROS : Reactive oxygen species -responsive poly(-amino ester) PCN-224: Porphyrin-based metalorganic framework PD1: Programmed cell death protein 1 PDK1: Pyruvate dehydrogenase kinase I PDT: Photodynamic therapy PEG: Polyethylene glycol PEG-PCL: [Poly(ethylene glycol) methyl ether-block-poly (-caprolactone) copolymers] PEI-PLGA: Polyethylenimine-poly(d,l-lactide-co-glycolide) PhA: Pheophorbide A p(HPMAm-Lacn): Poly(hydroxypropyl methacrylamide-lactate PLA 2 : Phospholipase A 2 pNIPAAm: Poly(N-isopoprylacrylamide) PNZ-Cl: P-nitrobenzyl chloroformate PMOA: Poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol)methacrylate-co-acrylic acid) PSA: Prostate specific antigen PTK-7: Tyrosine-protein kinase-like 7 receptor PTT: Photothermal therapy PVP: Polyvinylpyrrolidone QDs: Quantum dots RAFT: Reversible addition fragmentation chain transfer r-GO: Reduced graphene oxide ROS: Reactive oxygen species SEM: Standard error of mean ShRNA: Small hairpin RNA SPIONs: Supramagnetic nanoparticles SOD: Superoxide dismutase TALENs: Transcription activator-like effector nucleases TiO 2 : Titanium dioxide TME: Tumor microenvironment TPZ: Tirapazamine TUBB3: Tubulin beta 3 class III TUNEL: Terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling UCNs: Upconverting nanomaterials V 2 O 5 : Vandium pentoxide VEGF: Vascular endothelial growth factor V m : Membrane potential WO 3 : Tungsten trioxide ZnO: Zinc oxide ZnTcpp: Zinc metalated porphyrin C6 cells: Rat glioma cell line 1 O 2 : Singlet oxygen 4T1 cells: Breast cancer cell line derived from mammary glands 223Ra: Radium-223 99mTc: Technetium-99 90Y: Yttrium-90 177Lu: Lutetium-177 111In: Indium-111 59Fe: Iron-59 18FDG: 18F-2-fluoro-2-deoxyglucose References H

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Prescribers considering this formulation should be aware of the patient's overall health status, including any other medications being taken, to avoid potential drug interactions